Dalian Kexiang Technology Development Co. Ltd.

Fine-controlled in vitro percutaneous system
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Fine-controlled in vitro percutaneous system KX-V/HDP

1, Temperaturecontrollable (30~50±0.2°C);


2. Controllablespeed (300~1200±5% RPM);


3. Adjustable testmode (KX-10VPC / horizontal KX-5HPC conversion);


4. In line withthe FDA published local preparation BE replacement technical requirements for in vitro test and methodologicalresearch;


5. According totemperature and receptor solution’s viscosity, determine the speed, the datacan be obtained accurately reflect the skin's transdermal absorption of thedrug;


6, The experimental data obtained by the system,parameters of the drug percutaneous penetration kinetics can be analyzedthrough the TRANSDERMAL-CAD.





The Precision Controled Laboratory Coating Machine
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The precision controledlaboratory coating machine KX-FC-19HP

1 It is suitable forhigh-viscosity micro-test materials with 50~300ml coating at one time;


2、The coating area is uniform in thickness, and the coating thicknesserror is ~±5μm;


3、The thickness of Knife gap is precision controlled;


4Usingpatented coating technology, pressure-sensitive adhesive and other coatings tomake sure the pressure of the 2 parts remain the same;


5、Using screw and dual motor drive technology to ensure constant coatingspeed;


6、Using The grating ruler feedback technology to control the thicknessof the coating gap precisely electrically, at the same time make sure the error< ±5μm.


TRANSDERMAL-CAD
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In vitro percutaneous permeation data analysis and TTS optimization systemTRANSDERMAL-CAD

1Obtaining percutaneous permeation kinetic parameters (such as skinsurface concentration; stratum corneum diffusion rate; stratum corneum orepidermal partition coefficient; epidermal diffusion coefficient, etc.), whichguides prescription and process optimization efficiently;


2Analyzing the reason for percutaneous absorption of drugs(Infiltration, Binding, and Metabolism, etc.);


3Optimizing the design of pharmaceutics (drug concentration, preparationarea and thickness, etc.);


4Compareing similarities and differences between pharmaceuticals andRLDwhich can provide comprehensivedetailed datafor BE research in vitro;


5Analyzing and predicting the changes of drug concentration in thestratum corneum andepidermis;


6Analyzing and predicting the changes of time-drug concentration inblood.have toprovide pharmacokinetic parameters).

地址:大连高新技术产业园区高能街26号C座201室
电话:0411-81760803
邮箱:  daliankx@vip.163.com